Department of Experimental

Physiology and Pathophysiology

Department of Experimental

Physiology and Pathophysiology

Science

We are undertaking both experimental and theoretical investigations to examine the mechanisms underlying civilisation-related diseases, including hypertension, heart failure, arrhythmias, obesity, and diabetes.
We are focused on developing collaboration between research groups from various fields of knowledge in life sciences, exact sciences, and engineering, as well as commercial companies, to transfer modern technologies to the economy and healthcare.
In the Department of Physiology and Experimental Pathophysiology, the following grants are being implemented:
 

Grants:
NATIONAL SCIENCE CENTER

  • The impact of a keratin dressing enriched with M-CSF on wound healing in a type 2 diabetic rat model – pilot study (PRELUDIUM - 2024/53/N/NZ4/03697) - Project Leader: Dr. Mateusz Rybka, Supervisor: Dr. Hab. Marek Konop
  • (TNT-CVD) Trimethylamine as a Toxin in Cardiovascular Diseases. (UMO-2020/37/B/NZ5/00366, OPUS 19). Project Leader: Prof. Dr. Hab. Marcin Ufnal
  • The effect of indole-3-propionic acid, a bacterial metabolite of tryptophan, on the cardiovascular system in rats. (2019/35/N/NZ4/01111, Preludium 18), Project Leader: Dr. Piotr Konopelski
  • The role of piezoliths and osmolytes in the circulatory system in health and disease. (2018/31/B/NZ5/00038, OPUS 16), Project Leader: Prof. Dr. Hab. Marcin Ufnal
  • The involvement of gut bacteria and methylamines from intestinal microbiota in blood pressure regulation and the development of hypertension (2016/21/B/NZ5/02544, OPUS 11), Project Leader: Dr. Hab. Marcin Ufnal
  • The involvement of hydrogen sulfide and methane, metabolites of gut bacteria, in blood pressure regulation and the development of hypertension (2016/22/E/NZ5/00647, SONATA BIS 6), Project Leader: Dr. Hab. Marcin Ufnal
  • Pathological significance of trimethylamine-N-oxide in heart failure (2015/19/N/NZ5/00650, PRELUDIUM 10) – Project Leader: Dr. Adrian Drapała
     

INTERNAL GRANTS – Young Researcher Project

  • "The effect of trimethylamine on cholesterol metabolism", WLS14/2/M/MG/N/23/23 - Project Leader: Dr. Mateusz Szudzik
  • "Development of a model of poorly healing wounds in rats with iatrogenically induced type 2 diabetes and evaluation of the effectiveness of keratin dressing", WLS14/2/M/MB/N.FRN/24/24 - Project Leader: Dr. Mateusz Rybka
  • "The effect of sericin-based biomaterials on the inflammatory response, macrophage polarization, and activation of the AKT/mTOR pathway in vitro and in vivo in a surgical wound model in rats with induced diabetes", WLS14/3/M/MB/N/24/24 - Project Leader: Dr. Łukasz Mazurek
  • "The effect of a keratin dressing with trimethylamine-N-oxide on wound healing and inflammatory response in rats with iatrogenically induced diabetes", number: 21/M/MB/N/23 - Project Leader: Dr. Mateusz Rybka
  • The effect of keratin-based preparations on wound healing in rats with iatrogenically induced diabetes (MB/M/18(36)) - Project Leader: Dr. Marek Konop
  • Investigating the effect of gut microbiota metabolites on the growth of cardiovascular cells in in vitro culture (MB/M/02(4)) - Project Leader: Dr. Piotr Konopelski
  • Common neurohormonal mechanisms of regulation of intraocular pressure and blood pressure - (MB/M/20(40)) - Project Leader: Dr. Janusz Skrzypecki
     

INTERNAL GRANTS – Student Mini-Grants

  • "The role of GDF15 factor in the development of non-alcoholic fatty liver disease and cardiovascular diseases", number: 73/M/MG/N/23 - Project Leader: Mikołaj Zajdel, Supervisor: Dr. Mateusz Szudzik
  • "Evaluation of the effectiveness of a keratin dressing base on tissue response in a surgical wound model in healthy rats", number: 60/M/MG/N/23 - Project Leader: Łukasz Mazurek, Supervisor: Dr. Marek Konop
  • The effect of a keratin dressing with sodium acetate on macrophage polarization in the process of skin wound healing in type 1 diabetic rat models (1S7/3/M/MG/N/22/22) - Project Leader: Łukasz Mazurek, Supervisor: Dr. Marek Konop
  • The effect of a keratin dressing on macrophage polarization and PI3K-AKT signaling pathway activity in a surgical wound model in diabetic rats (1S7/1/M/MG/N/22/22), Project Leader: Mateusz Rybka, Supervisor: Dr. Marek Konop
  • The effect of a keratin dressing on wound healing and the expression of selected cytokines in a surgical wound model in rats with induced diabetes - (16/M/MG/N/21) - Project Leader: Mateusz Rybka, Supervisor: Dr. Marek Konop
  • The effect of a keratin dressing on wound healing and the expression of selected cytokeratins in a surgical wound model in rats with iatrogenically induced diabetes - (44/M/MG/N/21) - Project Leader: Łukasz Mazurek, Supervisor: Dr. Marek Konop
     

GRANTS “The Best of the Best! 4.0” from the Ministry of Education and Science (MEiN)

  • The effect of keratin-based preparations on wound healing in animals with pharmacologically induced diabetes (3rd edition). - Łukasz Mazurek, Supervisor: Dr. Marek Konop
     

GRANTS from the Ministry of Science and Higher Education (MNiSW) - Diamond Grants
 

  • The gut-blood barrier is a new marker and therapeutic target for hypertension, heart failure, and diabetes. K.N Jaworska, Supervisor: Dr. Hab. Marcin Ufnal
  • The role of indole in blood pressure regulation and the pathogenesis of hypertension. – P. Konopelski, Supervisor: Dr. Hab. Marcin Ufnal
     

We encourage you to familiarise yourself with our workshop and invite you to collaborate in scientific research!