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Publikacje

Najważniejsze publikacje Pracowników (lata 2016-2021, PubMed.):

Rok 2021:

  1. Zaorska E, Gawryś-Kopczyńska M, Ostaszewski R, Ufnal M, Koszelewski D. Evaluation of thionolactones as a new type of hydrogen sulfide (H2S) donors for a blood pressure regulation. Bioorg Chem. 2021 Jan 12;108:104650. doi: 10.1016/j.bioorg.2021.104650.
  2. Frączek, K.; Kowalczyk, A.; Pekala, M.; Kasarello, K.; Sygitowicz, G.; Sulejczak, D.; Zaremba, M.; Konop, M.; Frankowska, M.; Filip, M.; Bujalska-Zadrozny, M.; Kleczkowska, P. The Positive and Negative Outcome of Morphine and Disulfiram Subacute Co-Administration in Rats in the Absence of Ethanol Challenge. Pharmaceutics 2021, 13, 29.

Rok 2020:

  1. Skrzypecki J, Grabska-Liberek I, Guszkowska M, Izdebska J, Szaflik JP. Immersion Biometry for Intraocular Lens Power Calculation with Fourth-Generation Formulas. Clin Ophthalmol. 2020 Jul 28;14:2159-2162. doi: 10.2147/OPTH.S259078.
  2. Skrzypecki J, Ciepiaszuk K, Gawryś-Kopczyńska M. Low-dose Bevacizumab Decreases Ocular Hypotensive Effect of Angiotensin II in Sprague Dawley Rats. Curr Eye Res. 2020 Jun 22:1-8. doi: 10.1080/02713683.2020.1780264.
  3. Skrzypecki J, Izdebska J, Kamińska A, Badowska J, Przybek-Skrzypecka J, Bombuy J, Samborowska E, Szaflik JP. Glaucoma patients have an increased level of trimethylamine, a toxic product of gut bacteria, in the aqueous humor: a pilot study. Int Ophthalmol. 2020 Sep 11. doi: 10.1007/s10792-020-01587-y.
  4. Drapala A, Szudzik M, Chabowski D, Mogilnicka I, Jaworska K, Kraszewska K, Samborowska E, Ufnal M. Heart Failure Disturbs Gut-Blood Barrier and Increases Plasma Trimethylamine, a Toxic Bacterial Metabolite. Int J Mol Sci. 2020 Aug26;21(17):E6161. doi: 10.3390/ijms21176161.
  5. Jaworska K, Konop M, Hutsch T, Perlejewski K, Radkowski M, Grochowska M, Bielak-Zmijewska A, Mosieniak G, Sikora E, Ufnal M. Trimethylamine But Not Trimethylamine Oxide Increases With Age in Rat Plasma and Affects Smooth Muscle Cells Viability. J Gerontol A Biol Sci Med Sci. 2020 Jun 18;75(7):1276-1283. doi: 10.1093/gerona/glz181.
  6. Gawrys-Kopczynska M, Konop M, Maksymiuk K, Kraszewska K, Derzsi L, Sozanski K, Holyst R, Pilz M, Samborowska E, Dobrowolski L, Jaworska K, Mogilnicka IUfnal M. TMAO, a seafood-derived molecule, produces diuresis and reduces mortality in heart failure rats. Elife. 2020 Jun 8;9:e57028. doi: 10.7554/eLife.57028.
  7. Ufnal M, Trimethylamine, a Toxic Precursor of Trimethylamine Oxide, Lost in Medical Databases, The Journal of Nutrition, Volume 150, Issue 2, February 2020, Page 419, https://doi.org/10.1093/jn/nxz265
  8. Onyszkiewicz M, Jaworska K, Ufnal M, Short chain fatty acids and methylamines produced by gut microbiota as mediators and markers in the circulatory system, Exp Biol Med (Maywood). 2020 Jan 16:1535370219900898. doi: 10.1177/1535370219900898. 
  9. Mogilnicka I, Bogucki P, Ufnal M. Microbiota and Malodor-Etiology and Management. Int J Mol Sci. 2020 Apr 20;21(8). pii: E2886. doi:10.3390/ijms21082886.
  10. Onyszkiewicz M, Gawrys-Kopczynska M, Sałagaj M, Aleksandrowicz M, Sawicka A, Koźniewska E, Samborowska E, Ufnal M. Valeric acid lowers arterial blood pressure in rats. Eur J Pharmacol. 2020 Jun 15;877:173086. doi:10.1016/j.ejphar.2020.173086.
  11. Dawidowski M, Król M, Szulczyk B, Chodkowski A, Podsadni P, Konopelski PUfnal M, Szuberski P, Wróbel MZ, Zhang Y, El Harchi A, Hancox JC, Jarkovska D, Mistrova E, Sviglerova J, Štengl M, Popowicz GM, Turło J. Structure-activity relationship and cardiac safety of 2-aryl-2-(pyridin-2-yl)acetamides as a new class of broad-spectrum anticonvulsants derived from Disopyramide. Bioorg Chem.2020 May;98:103717. doi: 10.1016/j.bioorg.2020.103717.
  12. Zaorska E, Tomasova L, Koszelewski D, Ostaszewski R, Ufnal M. Hydrogen Sulfide in Pharmacotherapy, Beyond the Hydrogen Sulfide-Donors. Biomolecules. 2020 Feb 18;10(2). pii: E323. doi: 10.3390/biom10020323.
  13. Bochynska-Czyz M, Redkiewicz P, Kozlowska H, Matalinska J, Konop M, Kosson P.  Can Keratin Scaffolds be used for Creating Three-dimensional Cell Cultures? Open Med (Wars). 2020 Apr 3;15:249-253. doi: 10.1515/med-2020-0031.
  14. Skrzypecki J, Niewęgłowska K, Samborowska E. Valeric Acid, a Gut Microbiota Product, Penetrates to the Eye and Lowers Intraocular Pressure in Rats. Nutrients. 2020 Jan 31;12(2):387. doi: 10.3390/nu12020387. 

Rok 2019

  1. Onyszkiewicz M, Gawrys-Kopczynska M, Konopelski P, Aleksandrowicz M, Sawicka A, Koźniewska E, Samborowska E, Ufnal M. Butyric acid, a gut bacteria metabolite, lowers arterial blood pressure via colon-vagus nerve signaling and GPR41/43 receptors. Pflugers Arch. 2019 Dec;471(11-12):1441-1453. doi: 10.1007/s00424-019-02322-y. 
  2. Konop M, Czuwara J, Kłodzińska E, Laskowska AK, Sulejczak D, Damps T, Zielenkiewicz U, Brzozowska I, Sureda A, Kowalkowski T, Schwartz RA, Rudnicka L. Evaluation of keratin biomaterial containing silver nanoparticles as a potential wound dressing in full-thickness skin wound model in diabetic mice. J Tissue Eng Regen Med. 2019 Dec 11. doi: 10.1002/term.2998.
  3. Jaworska K, Bielinska K, Gawrys-Kopczynska M, Ufnal M. TMA (trimethylamine), but not its oxide TMAO (trimethylamine-oxide), exerts haemodynamic effects: implications for interpretation of cardiovascular actions of gut microbiome. Cardiovascular Research, , cvz231, https://doi.org/10.1093/cvr/cvz231
  4. Jaworska, K.; Hering, D.; Mosieniak, G.; Bielak-Zmijewska, A.; Pilz, M.; Konwerski, M.; Gasecka, A.; Kapłon-Cieślicka, A.; Filipiak, K.; Sikora, E.; Hołyst, R.; Ufnal, M. TMA, A Forgotten Uremic Toxin, but Not TMAO, Is Involved in Cardiovascular Pathology. Toxins 201911, 490.
  5. Jaworska K, Konop M, Hutsch T, Perlejewski K, Radkowski M, Grochowska M, Bielak-Zmijewska A, Mosieniak G, Sikora E, Ufnal M. TMA but not TMAO increases with age in rat plasma and affects smooth muscle cells viability, The Journals of Gerontology: Series A, 2019 Aug 14;https://doi.org/10.1093/gerona/glz181.
  6. Jaworska K, Konop M, Bielinska K, Hutsch T, Dziekiewicz M, Banaszkiewicz A, Ufnal M. Inflammatory bowel disease associates with increased gut-to-blood penetration of SCFA: A new, noninvasive marker of a functional intestinal lesion. Exp Physiol. 2019 Jun 26. doi: 10.1113/EP087773.
  7. Ufnal M, Hutsch T. Colonic Delivery of H2S Donors for Studying Cardiovascular Effects of H2S in Rats. Methods Mol Biol. 2019;2007:173-177. doi: 10.1007/978-1-4939-9528-8_13.
  8. Ufnal M, Nowinski A. Central Administration of H2S Donors for Studying Cardiovascular Effects of H2S in Rats. Methods Mol Biol. 2019;2007:167-172. doi: 10.1007/978-1-4939-9528-8_12.
  9. Zaorska E, Hutsch T, Gawryś-Kopczyńska M, Ostaszewski R, Ufnal M, Koszelewski D. Evaluation of thioamides, thiolactams and thioureas as hydrogen sulfide (H2S) donors for lowering blood pressure. Bioorg Chem. 2019 Jul;88:102941. doi: 10.1016/j.bioorg.2019.102941.
  10. Konopelski P, Konop M, Gawrys-Kopczynska M, Podsadni P, Szczepanska A, Ufnal M. Indole-3-Propionic Acid, a Tryptophan-Derived Bacterial Metabolite, Reduces Weight Gain in Rats. Nutrients. 2019 Mar 11;11(3).
  11. Skrzypecki J, Huc T, Ciepiaszuk K, Ufnal M. Effect of TMAO, a Gut-Bacteria Metabolite, on Dry Eye in a Rat Model. Curr Eye Res. 2019 Jan 31. doi: 10.1080/02713683.2019.1574834.
  12. Skrzypecki J, Ufnal M, Szaflik JP, Filipiak KJ. Blood pressure and glaucoma: At the crossroads between cardiology and ophthalmology. Cardiol J. 2019;26(1):8-12. doi: 10.5603/CJ.2019.0008.
  13. Mogilnicka I, Ufnal M. Gut Mycobiota and Fungal Metabolites in Human Homeostasis. Curr Drug Targets. 2019;20(2):232-240. doi:10.2174/1389450119666180724125020.
  14. Konop M, Kłodzińska E, Borowiec J, Laskowska AK, Czuwara J, Konieczka P, Cieślik B, Waraksa E, Rudnicka L. Application of micellar electrokinetic chromatography for detection of silver nanoparticles released from wound dressing. Electrophoresis. 2019 Mar 8. doi: 10.1002/elps.201900020. 
  15. Waraksa E, Pokrywka A, Konop M, Namieśnik J, Kłodzińska E. Comparison of GC-MS and MEKC methods for caffeine determination in preworkout supplements. Electrophoresis. 2019 Mar 6. doi: 10.1002/elps.201800512. 
  16. Waraksa E, Filipiak W, Kłodzińska E, Ozimek M, Konop M, Namieśnik J. Nonsteroidal anti-inflammatory drug metabolism studies in horses in view of doping control: analytical strategies and challenges. Anal. Methods, 2019,11, 3767-3792 
  17. Liu M, Borowiec J, Sun LJJ, Konop M, Rahman MM, Taallah A, et al. Experimental studies on the conduction mechanism and electrical properties of the inverted Ba doped ZnO nanoparticles based memristor. Appl Phys Lett. 2019 Aug 12;115(7):073505.
  18. Filip-Hutsch K, Hutsch T, Kołosa S, Demiaszkiewicz A. First description of histopathological lesions associated with a fatal infection of moose (Alces alces) with the liver fluke Parafasciolopsis fasciolaemorpha Ejsmont, 1932, J Vet Res 63, 2019 DOI:10.2478/jvetres-2019-0068.
  19. Bronowicka-Adamska P, Hutsch T, Gawryś-Kopczyńska M, Maksymiuk K, Wróbel M. Hydrogen sulfide formation in experimental model of acute pancreatitis, Acta Bioch Pol, December 4.2019 (ref. n. 2900). 

Rok 2018

  1. Huc T, Drapala A, Gawrys M, Konop M, Bielinska K, Zaorska E, Samborowska E, Wyczalkowska-Tomasik A, Pączek L, Dadlez M, Ufnal M. Chronic, low-dose TMAO treatment reduces diastolic dysfunction and heart fibrosis in hypertensive rats,  Am J Physiol-Heart and Circulatory Physiology. 2018. 
  2. Jaworska K, Huc T Gawrys M, Onyszkiewicz M, Samborowska E, Ufnal M. An In Vivo Method for Evaluating the Gut-Blood Barrier and Liver Metabolism of Microbiota Products, JOVE 2018 Sep.
  3. Huc T, Konop M, Onyszkiewicz M, Podsadni P, Szczepanska A, Turlo J, Ufnal M. Colonic indole, gut bacteria metabolite of tryptophan, increases portal blood pressure in rats. Am J Physiol Regul Integr Comp Physiol. 2018 May 30. doi:10.1152/ajpregu.00111.2018. 
  4. Zaorska E, Konop M, Ostaszewski R, Koszelewski D, Ufnal M. Salivary Hydrogen Sulfide Measured with a New Highly Sensitive Self-Immolative Coumarin-Based Fluorescent Probe. Molecules. 2018 Sep 3;23(9). 
  5. Drapała A, Bielińska K, Konopelski P, Pączek L, Ufnal M. His-Leu, an angiotensin I-derived peptide, does not affect haemodynamics in rats. J Renin Angiotensin Aldosterone Syst. 2018 Oct-Dec;19(4):1470320318808879.
  6. Skrzypecki J, Żera T, Ufnal M. Butyrate, a Gut Bacterial Metabolite, Lowers Intraocular Pressure in Normotensive But Not in Hypertensive Rats. J Glucoma. 2018 Sep;27(9):823-827.
  7. Konop M, Czuwara J, Kłodzińska E, Laskowska A.K, Zielenkiewicz U, Brzozowska I, Nabavi S.M, Rudnicka L. Development of a novel keratin dressing which accelerates full-thickness skin wound healing in diabetic mice: in vitro and in vivo studies. J. Biomater. Appl. 2018 Sep 18; DOI: doi.org/10.1177/0885328218801114.
  8. Mogilnicka I, Ufnal M. Gut Mycobiota and Fungal Metabolites in Human Homeostasis. Curr Drug Targets. 2018 Jul 24. doi: 10.2174/1389450119666180724125020.
  9. Konopelski P, Ufnal M. Indoles - gut bacteria metabolites of tryptophan with pharmacotherapeutic potential. Curr Drug Metab. 2018 Apr 27. doi: 10.2174/1389200219666180427164731. 
  10. Skrzypecki J, Żera T, Ufnal M. Butyrate, a Gut Bacterial Metabolite, Lowers Intraocular Pressure in Normotensive But Not in Hypertensive Rats. J Glaucoma. 2018 Sep;27(9):823-827.
  11. Huć T, Nowinski A, Drapala A, Konopelski P, Ufnal M. Indole and indoxyl sulfate, gut bacteria metabolites of tryptophan, change arterial blood pressurevia peripheral and central mechanisms in rats. Pharmacol Res. 2018 Apr;130:172-179. 
  12. Bielinska K, Radkowski M, Grochowska M, Perlejewski K, Huc T, Jaworska K, Motooka D, Nakamura S, Ufnal M. High salt intake increases plasma trimethylamine N-oxide (TMAO) concentration and produces gut dysbiosis in rats. Nutrition. 2018 Mar 22;54:33-39. 
  13. Skrzypecki J, Grabska-Liberek I, Przybek J, Ufnal M. A common humoral background of intraocular and arterial blood pressure dysregulation. Curr Med ResOpin. 2018 Mar;34(3):521-529.
  14. Nowiński A, Ufnal M. Trimethylamine N-oxide: A harmful, protective or diagnostic marker in lifestyle diseases? Nutrition. 2018 Feb;46:7-12. 
  15. Konop M, Radkowski M, Grochowska M, Perlejewski K, Samborowska E, Ufnal M. Enalapril decreases rat plasma concentration of TMAO, a gut bacteria-derived cardiovascular marker. Biomarkers. 2018 May - Jun;23(4):380-385. 
  16. Huc T, Jurkowska H, Wróbel M, Jaworska K, Onyszkiewicz M, Ufnal M. Colonic hydrogen sulfide produces portal hypertension and systemic hypotension in rats. Exp Biol Med (Maywood). 2018 Jan;243(1):96-106. 
  17. Kowalczyk A, Kleczkowska P, Konop M, et al. Determination of the anti-inflammatory properties and analgesic activity of the AA3052 chimeric peptide against CFA-induced inflammatory pain. Animal Science Papers & Reports, 2018;36(2):219-239.
  18. Nowiński A, Ufnal M. Gut bacteria-derived molecules as mediators and markers in cardiovascular diseases. The role of the gut-blood barrier. Kardiol Pol.2018;76(2):320-327. 

        Rok 2017

  1. Ufnal M, Pham K. The gut-blood barrier permeability - A new marker in cardiovascular and metabolic diseases? Med Hypotheses. 2017 Jan;98:35-37. 
  2. Drapala A, Koszelewski D, Tomasova L, Ostaszewski R, Grman M, Ondrias K, Ufnal M. Parenteral Na(2)S, a fast-releasing H(2)S donor, but not GYY4137, a slow-releasing H(2)S donor, lowers blood pressure in rats. Acta Biochim Pol. 2017;64(3):561-566.
  3. Skrzypecki J, Gawlak M, Huc T, Szulczyk P, Ufnal M. Renal denervation decreases blood pressure and renal tyrosine hydroxylase but does not augment the effect of hypotensive drugs. Clin Exp Hypertens. 2017;39(3):290-294. 
  4. Wołyńczyk-Gmaj D, Różańska-Walędziak A, Ziemka S, Ufnal M, Brzezicka A, Gmaj B, Januszko P, Fudalej S, Czajkowski K, Wojnar M. Insomnia in Pregnancy Is Associated With Depressive Symptoms and Eating at Night. J Clin Sleep Med. 2017 Oct 15;13(10):1171-1176.
  5. Skrzypecki J,  Ufnal M. The Upright Body Position Increases Translaminar Pressure Gradient in Normotensive and Hypertensive Rats. Curr Eye Res. 2017 Dec;42(12):1634-1637
  6. Walacik-Ufnal E, Piotrowska AJ, Wołyńczyk-Gmaj D, Januszko P, Gmaj B, Ufnal M, Kabat M, Wojnar M. Narcolepsy type 1 and hypersomnia associated with a psychiatric disorder show different slow wave activity dynamics. Acta Neurobiol Exp (Wars). 2017;77(2):147-156. 
  7. Tomasova L, Drapala A, Jurkowska H, Wróbel M, Ufnal M. Na(2)S, a fast-releasing H(2)S donor, given as suppository lowers blood pressure in rats. Pharmacol Rep. 2017 Oct;69(5):971-977. 
  8. Jaworska K, Huc T, Samborowska E, Dobrowolski L, Bielinska K, Gawlak M, Ufnal M. Hypertension in rats is associated with an increased permeability of the colon to TMA, a gut bacteria metabolite. PLoS One. 2017 Dec 13;12(12):e0189310. 
  9. Skrzypecki J, Przybek J. Physician Review Portals Do Not Favor Highly Cited US Ophthalmologists. Semin Ophthalmol. 2018;33(4):547-551.

        Rok 2016

  1. Konopelski P, Ufnal M. Electrocardiography in rats: a comparison to human. Physiol Res. 2016 Nov 23;65(5):717-725.
  2. Sikora M, Konopelski P, Pham K, Wyczalkowska-Tomasik A, Ufnal M. Repeated restraint stress produces acute and chronic changes in hemodynamic parameters in  rats. Stress. 2016 Nov;19(6):621-629.
  3. Król M, Ufnal M, Szulczyk B, Podsadni P, Drapała A, Turło J, Dawidowski M. Characterization of Disopyramide derivative ADD424042 as a non-cardiotoxic neuronal sodium channel blocker with broad-spectrum anticonvulsant activity in rodent seizure models. Eur J Pharm Sci. 2016 Jan 1;81:42-51.  
  4. Tomasova L, Konopelski P, Ufnal M. Gut Bacteria and Hydrogen Sulfide: The New Old Players in Circulatory System Homeostasis. Molecules. 2016 Nov 17;21(11).
  5. Sikora M, Pham K, Ufnal M. Hypotensive effect of S-adenosyl-L-methionine in hypertensive rats is reduced by autonomic ganglia and KATP channel blockers. Amino Acids. 2016 Jul;48(7):1581-90.
  6. Tomasova L, Dobrowolski L, Jurkowska H, Wróbel M, Huc T, Ondrias K, Ostaszewski R, Ufnal M. Intracolonic hydrogen sulfide lowers blood pressure in rats. Nitric Oxide. 2016 Nov 30;60:50-58. 
  7. Huc T, Pham K, Skrzypecki J, Ufnal M. Significance of gut-blood barrier in healthy and disease. European Journal of Biological Research, 2016 Aug, v. 6, n. 3, p. 193-200.